Liz Donohoe carried Oklahoma State with a game-high 22 points, while Toni Young recorded 18 points and 13 boards.
For the game, TCU, who outscored the Cowgirls off the bench a whopping 25-0, out-rebounded OSU, 39-38. The Frogs also recorded an 18-14 advantage in second-chance points Wednesday.
Kamy Cole opened the second half, swatting away a would-be shot on one end and then drilling a trey ball on the other to give TCU a 40-38 lead on the opening possession. OSU regained the lead at 44-41 a few moments later off a 6-1 run, but the Frogs calmed the storm at the charity stripe, pulling back ahead at 45-44 with 15:17 left in the second half.
Following a mini-run by Oklahoma State, Cole knotted the game at 48-48 off a running layup midway through the period. TCU regained the lead at 49-48 thanks to all out hustle by Gross, but the Cowgirls responded by going up 54-49 on back-to-back three-pointers.
With the scoreboard reading 60-51 in slight favor of OSU down the stretch, Latricia Lovings corralled a loose ball and put it back up to make it 60-53. Following a three by Oklahoma State, Medley banked home a triple of her own to pull the score to 63-56 with 4:45 showing.
By the time Ventress dropped in a jumper at the 3:25 mark, TCU was in the midst of a 8-3 run, which made the score 63-59 with a little over two minutes to go in the game.
Medley then made one of the biggest buckets of the game, nailing a deep three at the 1:59 mark to pull the Frogs within one at 63-62. On the very next possession, Gross grabbed a rebound and powered home a layup to push the Frogs ahead at 64-63.
Veja Hamilton got the Frogs going early, nailing a jumper on the opening possession to give TCU a 2-0 lead. TCU continued to roll the next trip down the court as Ventress tickled the twine from deep almost two minutes into the contest.